CR31 UKK – Klinikum der Universität zu Köln (Gemrnay)
Center for Genomics
Dr. Thomas Sander, ph.
+49 221 4701350, fax +49 221 4701595, email@example.com
Expertise and current research
performed: The Cologne
Center for Genomics (CCG)
represents one of the main national genotyping platforms of the German Genome
Research Network. The neurogenetics group has a long track record in gene
mapping studies of neuropsychiatric disorders, and, in particular, molecular
genetic studies on common IGE syndromes. Since 1999 genome-wide linkage studies
have been performed in 279 IGE-multiplex families, which were collected by an
European concerted action. T. Sander is an experienced epileptologist with
extensive expertise in molecular genetics and biostatistical methods of linkage
and linkage disequilibrium mapping. Current molecular genetic studies are
supported by two grants funded by the Deutsche Forschungsgemeinschaft (DFG) and
the Federal Ministry of Education, Research and Technology (BMBF).
CCG is equipped for high-throughput genotyping of SNPs and STR polymorphisms.
List of equipment: one ABI 3730 Sequence Analyzer, 5 ABI 9700 PCR Thermocycler, one ABI Prism 7900 HT System, Pyrosequencing,
TaqMan, SNPstream, array-based technologies for genome-wide SNP genotyping
technologies (Affymetrix, Illumina) and comparative genomic hybridisation, bioinformatics
in the project
Sander, (M). Dr. (MD). Senior scientist.
Head of the neurogenetics group. He has a long track record in molecular
genetic studies on common IGE syndromes. Thomas Sander is an experienced
epileptologist and molecular geneticist. His expertise also comprises
biostatistical methods of linkage and linkage disequilibrium mapping.
Nürnberg, (M) Full professor, human genetics. Head of the CCG. Research interests:
linkage and linkage disequilibrium mapping of Mendelian and genetically complex
traits, genomic copy number variations. Janine Altmüller, (F) geneticist.
Research interests: linkage and linkage disequilibrium mapping of genetically
complex traits. Mohammad Toliat, (M) biologist. Research interests:
high-throughput genotyping technologies, quantitative allele specific gene
expression. Christian Becker, (M)
biotechnologist. Research interests: array-based genotyping and expression
analyses. Andreas Wollstein (M)
bioinformatician. Research interests: Statistical analyses of complex genetics
traits; data management. Elisabeth Kirst, (F) research technician. Nina
Dalibor, (F) research technician. Peter Wolf, (M) Danish Epilepsy Centre. M.D. Professor of epileptology at the
Danish Epilepsy Centre and the National
Hospital in Copenhagen. Previously, medical director of
Bethel Epilepsy Centre, Germany.
Working in the field since around 1975. Research interests within many areas of
epileptology. The Danish Epilepsy Centre, Dianalund is the only epilepsy
hospital in Denmark.
Patients are received from the whole country, and most patients are difficult
to diagnose, classify or treat. Christian Hansen (M) M.D., medical director at the Danish
Epilepsy Centre, Dianalund. Working in the field of epileptology since 1999.
Main research interest is the genetics of epilepsy. Moeller Rikke (F). Ph.D. student. Master of biomedicine. Main
research interest is genetics of epilepsy. Ulrich Stephani (M), University Hospital,
Kiel. Prof. Dr. (medicine), director of the
Department of Neuropediatrics and director of the epilepsy centre for children
and adolescents at University of Kiel
(both since 1992). Working in pediatric epileptology since 1989. Research
interests are: Clinical, neurophysiologic and (molecular) genetic
characterisation and therapy of epilepsy syndromes and other paroxysmal
disorders. Treatment studies in epileptology. Neurophysiology of headache/migraine.
The Department of Neuropediatrics and the associated Epilepsy centre for
children and adolescents is the reference center in the field of non-surgical
pediatric and adolescent epileptology and other paroxysmal disorders in Northern Germany. Since about five decades clinical and
molecular genetics in epileptology concerning epilepsy syndromes and
electroencephalography are the major focus. A large family cohort with
different epilepsy phenotypes and EEG-endophenotypes has been collected and
carefully recorded (incl. storage of DNA samples of the family members).
Specific activities deal with functional MRI in combination with EEG in
patients with focal epilepsies. Mark Gardiner (M), University College
London. MB BCh (1972). Professor of Paediatrics
at UCL from 1991. Working in field of molecular genetics since 1986. Research
interests in molecular genetics of inherited disorders of childhood onset with
a focus on neurogenetics including genetics of epilepsies and neuronal ceroid
Hempelmann A, Taylor KP,
Heils A, Lorenz S, et al. (2006) Exploration of the genetic architecture of
idiopathic generalized epilepsy. Epilepsia 47:1682-90.
U, Lorenz S, Lenzen KP, Heils A, Stephani U, Sander T (2005) Genetic dissection
of photosensitivity and its relation to idiopathic generalized epilepsy. Ann. Neurol. 57:866-73.
3. Lenzen KP, Heils A, Lorenz S, Hempelmann A,
Sander T (2005) Association analysis of the malic enzyme 2 gene polymorphisms
with idiopathic generalized epilepsy. Epilepsia
4. Haug K, Warnstedt M, Alekov AK, Sander T, et al. (2003) Mutations in CLCN2 encoding a
voltage-gated chloride channel are associated with idiopathic generalized
epilepsies. Nat Genet. 33:527-32.
C, Haug K, Sander T, et al. (2002) A splice-donor-site
mutation in GABRG2 causes childhood absence epilepsy and febrile
convulsions. Arch Neurol. 59:1137-41.