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PIP: Despite the fact that 8 cock are 8 million new cases of tuberculosis TB annually and 3 million deaths, TB has been a neglected public health priority, primarily because effective chemotherapy has led to a dramatic decrease in cases in industrialized countries and most cases in developing countries occur in adults.

It has only been recently that the emergence of multi-drug resistant TB and the rapid disease progression in HIV-infected persons has led to the application of the methods of modern basic science to TB.

Population movement among refugees and immigrants and the neglect of the public health infrastructure have also led to increases in the of cases worldwide. In developing countries, the TB seen in association with HIV is believed to be reactivation of latent infection. HIV-associated cases of TB will continue to increase in Africa, but in the future the largest of co-infected persons will be in Asia.

The clinical manifestations of HIV-related TB become more severe according to the progression of the immunodeficiency.

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Being HIV-positive is also associated more often 8 cock sputum-negative pulmonary or extrapulmonary TB and with atypical radiological manifestations such as absence of cavitation, absence of localization to the upper zones, and the presence of hilar adenopathy, effusions, or infiltrates.

Diagnosis may, therefore, be more difficult in cases of HIV infection. Although a greater mortality is found in HIV-positive patients perhaps 8 cock with complications of other bacterial infectionsTB can be treated successfully in HIV-infected people. The World Health Organization recommends short-course chemotherapy of isoniazid, rifampicin, ethambutol, and pyrazinamind for 2 months followed by 4 months of isoiazid and rifampicin or 6 months of isoniazid and ethambutol. The risk of recurrence is greater if non-rifampicin regimens are used and is times greater than in seronegative cases.

Proposed solutions to this problem are to replace thiacetazone with another drug, replace thiacetazone only in HIV-positive persons testing all patients for HIVor educating staff and patients about the need to discontinue the drug if a rash occurs. Donor funding will be necessary to adopt a single worldwide approach with the least side effects. Policy decisions must also be made to create a programmatic approach to preventing HIV-associated TB.

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Abstract PIP: Despite the fact that there are 8 million new cases of tuberculosis TB annually and 3 million deaths, TB has been a neglected public health priority, primarily because effective chemotherapy has led to a dramatic decrease in cases in industrialized countries and most cases in developing countries occur in adults. Disease Actions. Infections Actions. Virus Diseases Actions. Copy Download.

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